Publications
Peer-reviewed manscripts
1. Ismaeel A, Goh J, Mobley CB, Murach KA, Brett JO, de Morrée A, Rando TA, Peterson CA, Wen Y, McCarthy JJ. Division-Independent Differentiation of Muscle Stem Cells During a Growth Stimulus. Stem Cells. 2023 Online ahead of print.
2. Andersen OE, Poulsen JV, Farup J, de Morrée A. Regulation of adult stem cell function by ketone bodies. Front Cell Dev Biol. 2023 Aug 31
3. Das Barman S, Frimand Z, de Morrée A. Absolute quantification of mRNA isoforms in adult stem cells using microfluidic digital PCR. Bio Protoc. 2023 Sep 5
4. de Morree A, Rando TA. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity. Nature Reviews Mol Cell Biol. 2023 Mar 15
5. Benjamin DI, Brett JO, Both P, Benjamin JS, Ishak HL, Kang J, Kim S, Chung M, Arjona M, Nutter CW, Tan JH, Krishnan AK, Dulay H, Louie SM, de Morree A, Nomura DK, Rando TA. Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging. Cell Metabolism. 2023 Mar 7
6. Frimand Z, Das Barman S, Kjær TR, Porpiglia E, de Morrée A. Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles. J Vis Exp. 2022 Dec 9
7. Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. Cell Stem Cell. 2022 Dec 1
8. Ming J, Lin Z, Zhao J, Wan X; Tabula Microcebus Consortium; Yang C, Wu AR. FIRM: Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets. Brief Bioinform. 2022 Sep 20
9. Benjamin DI, Both P, Benjamin JS, Nutter CW, Tan JH, Kang J, Machado LA, Klein JDD, de Morree A, Kim S, Liu L, Dulay H, Feraboli L, Louie SM, Nomura DK, Rando TA. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metababolism 2022 June 7.
10. The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 May 13
11. Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets. Zhao J, Wang G, Ming J, Lin Z, Wang Y, The Tabula Microcebus Consortium, Wu AR, Yang C. Nature Computational Science. 2022 volume 2, 317–330 .
12. Salvi JS, Kang J, Kim S, Colville AJ, de Morrée A, Billeskov TB, Larsen MC, Kanugovi A, van Velthoven CTJ, Cimprich KA, Rando TA. ATR activity controls stem cell quiescence via the cyclin F-SCF complex. PNAS 2022 May 3
13. Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium, Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T. Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature. 2022 Mar 02
14. Vorperian SK, Moufarrej MN; Tabula Sapiens Consortium, Quake SR. Vorperian SK, Moufarrej MN; Tabula Sapiens Consortium, Quake SR.Nat Biotechnol. 2022 Feb 7. Nature Biotechnology 2022 Feb 7.
15. Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Wu AR, Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J. RNA splicing programs define tissue compartments and cell types at single cell resolution. Elife. 2021 in press
16. The Tabula Muris Consortium. Tabula Muris Senis: A Single Cell Atlas of Aging Tissues in the Mouse. Nature. 2020 Jul 15. doi: 10.1038/s41586-020-2496-1.
17. The Tabula Muris Consortium. Ageing hallmarks exhibit organ-specific temporal signatures. Nature 2020 Jul 15 doi:10.1038/s41586-020-2499-y.
18. Brett JO, et al. Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1. Nature Metabolism. 2020 (2): 307–317.
19. de Morrée A, Klein JDD, Gan Q, Farup J, Urtasun A, Kanugovi A, Bilen B, van Velthoven CTJ, Quarta M, Rando TA. Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function. Science. 2019 Nov 8;366(6466):734-738.
20. The Tabula Muris Consortium. Transcriptomic characterization of 20 organs and tissues from mouse at single cell resolution creates a Tabula Muris. Nature. 2018 Oct;562(7727):367-372.
21. van Velthoven CTJ, de Morrée A, Egner IM, Brett JO, Rando TA. Transcriptional profiling of quiescent muscle stem cells in vivo. Cell Reports. 2017 Nov 14;21(7):1994-2004.
22. de Morrée A, van Velthoven C, Gan Q, Salvi JS, Klein DD, Akimenko I, Quarta M, Biressi S, Rando TA. Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence. PNAS. 2017 Oct 24;114(43).
23. Luo D*, de Morrée A*, Boutet S, Quach N, Natu V, Rustagi A, Rando TA. Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. PNAS. 2017 Apr 11;114(15). * shared first authorship
24. Quarta M, Brett JO, DiMarco R, de Morrée A, Boutet SC, Cachon R, Gibbons M, Su J, Heilshorn S, Rando TA. A Bioengineered Niche Preserves Stem Cell Quiescence and Enhances Therapeutic Potential. Nature Biotechnology. 2016 Jul;34(7):752-9.
25. de Morrée A, Flix B, Bagaric I, Wang J, van den Boogaard M, Grand Moursel L, Frants RR, Illa I, Gallardo E, Toes R, van der Maarel SM. Dysferlin regulates cell adhesion in human monocytes. Journal of Biological Chemistry 2013 288: 14147-14157.
26. Humphrey GW, Mekhedov E, Blank PS, de Morrée A, Pekkurnaz G, Nagaraju K, Zimmerberg J. GREG cells, a dysferlin-deficient myogenic mouse cell line. Experimental Cell Research 2012 Jan 15;318(2):127-35.
27. Gallardo E, de Luna N, Diaz-Manera J, Rojas-García R, Paradas C, Flix B, Gonzalez-Quereda L, Hankiewicz K, Gich I, de Morrée A, van der Maarel SM, Illa I. Dysferlin blood test as a biomarker of muscular dystrophies: clinical, genetic, and muscle biopsy studies in a case series. PLoS One 2011;6(12):e29061.
28. de Morrée A, Droog M, Grand Moursel L, Bisschop IJM, Impagliazzo A, Frants RR, Klooster R, van der Maarel SM. Self-regulated alternative splicing at the AHNAK locus. FASEB journal 2012 Jan;26(1):93-103.
29. van Haagen HHHBM, ’t Hoen PAC, de Morrée A, van Roon-Mom WM, Peters DJ, Mons B, Schuemie MJ. Improved prediction of protein-protein interactions after integration of different biological databases. Proteomics 2011 Mar;11(5):843-53.
30. de Morrée A, Hensbergen PJ, van Haagen HHBM, Dragan I, Frants RR, van der Maarel SM. Proteomic analysis of the dysferlin protein complex shows its importance for sarcolemmal maintenance and integrity. PLoS One 2010 Nov 05 10.1371.
31. de Morrée A, Lutje Hulsik D, Impagliazzo A, van Haagen HHHBM, de Galan P, van Remoortere A, ’t Hoen PAC, van Ommen GJB, Frants RR, van der Maarel SM. Calpain 3 is a rapid-action, unidirectional proteolytic switch central to muscle remodeling. PLoS One 2010 Aug 4;5(8):e11940.
32. van Haagen HHHBM, 't Hoen PA, Botelho Bovo A, de Morrée A, van Mulligen EM, Chichester C, Kors JA, den Dunnen JT, van Ommen GJ, van der Maarel SM, Kern VM, Mons B, Schuemie MJ. Novel protein-protein interactions inferred from literature context. PLoS One 2009 Nov 18;4(11):e7894.
33. Huang Y*, de Morrée A*, van Remoortere A, Bushby K, Frants RR, den Dunnen J, van der Maarel SM. Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle. Human Molecular Genetics 2008 Jun 15;17(12):1855-66. * shared first authorship
34. Smolenaars MM, de Morrée A, Kerver J, Van der Horst DJ, Rodenburg KW. Insect lipoprotein biogenesis depends on an amphipathic beta cluster in apolipophorin II/I and is stimulated by microsomal triglyceride transfer protein. Journal of Lipid Research 2007 Sep;48(9):1955-65.
Columns and opinions (selected)
1. de Morrée A and Alvarez A. Institutions’ role in post-pandemic response. Science 2021 Sep 17.
2. de Morrée A, Gordon CA, Collman F, Klabunde M. United we stand. Nature 2017 Sep 28 (549):555.
3. de Morrée A. Molecular modeling to study protein function, J Cell Sci Ther 2015, 6:2.
4. de Morrée A. Outside the Tower: A Night at the Museum. Science 2014 Jul 18;345(6194):279.
5. de Morrée A. NextGen VOICES 7 survey. Science 5 July 2013: vol. 341 no. 6141 pp. 28-30.
Books
1. Lipp C and de Morrée A. Magnetic: How Great Leaders Persuade and Inspire. Kendal-Hunt Publishing 2021 Link to Amazon
2. Lipp C and de Morrée A. Becoming Magnetic: A Communication Handbook For Future Leaders. Kendal-Hunt Publishing 2020 Link to Amazon